Monday, January 18, 2021

Mucinous adenocarcinoma of the colon

 

Key points


1. Higher incidence of RAS/MAPK mutations

2. Overexpression of mucin genes

3. Higher expression of MSI-H and association with Lynch syndrome

4. Resistant to chemo. Prognosis compared to standard adenocarcinoma debatable.

5. Mostly proximal colon and appendix. More in females and diagnosed at advanced stage.

6. More LN involvement and peritoneal involvement

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