Reference: Blood Journal Sept 2025
IMS/IMWG recommendations for the definition of HR MM
| Criteria for HR MM |
|---|
| Del(17p) defined by FISH on CD138-purified cells with CCF >20% |
| TP53 mutation defined with NGS-based methodologies on CD138-purified cells |
| t(4;14), t(14;16), or t(14;20) if co-occurring with 1q gain/amplification∗ and/or del(1p32) |
| Monoallelic del(1p32) occurring with 1q gain/amplification |
| Biallelic del(1p32) |
| β2M >5.5 mg/dL in the context of preserved renal function and creatinine <1.2 mg/dL |
FISH, fluorescence in situ hybridization; NGS, next-generation sequencing.
∗
1q+, gain (3 copies) or amplification (≥4 copies) of the long arm of chromosome 1.
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