Relapsed refractory Hodgkin lymphoma treatment: Nivo with ICE

 

Standard of care for RR HL--> salvage chemo followed by ASCT

Standard chemo yields 54 to 73% PET neg CR which is the most imp predictor of outcomes.

BV with nivo ( no chemo) salvage--> 67%

However, BV is now being used frontline.

Nivo monotherapy --> 27 to 43% CR without chemo.

PET adapted sequential nivo followed by nivo with ICE

Nivo q 2 weeks up to 6 doses. If CR-->ASCT

If not CR after 6 cycles or PD at any point, then 2 cycles ICE+ nivo--> ORR over 90%

2 yr PFS all comer 72% 2 yr OS 95%