Shelf life of blood products
- RBC- 42 days with AS1, 4 degrees C
- Platelets- 5 days at room temp
- FFP: Plasma: frozen within 8 hr of collection at minus 18 C for 1 yr, once thawed use within 5 days
- PF24 is plasma frozen within 24 hr ( not 8 hr)
- Cryoprecipitate: when FFP is thawed at 4 degrees and the supernatant is centrifuged, the precipitate is called cryoppt. Rich is fibrinogen, fibronectin, Factor 8, 13 and VWAg.
Plasma (FFP) versus cryoprecipitate
- plasma contains procoagulant and natural anticoagulant, so use for TTP, DIC, liver failure etc
- cryo was used to correct fibrinogen def, hemophilia and VWD although now specific factors are available
FFP dose 10-30 ml/kg bwt
Cryoppt dose: 10-20 donor units
Blood journal Feb 2025: How I treat fibrinogen disorders
Fibrinogen deficiency states: maintain fibrinogen trough 100 mg/dl and aim for > 150 mg/dl
DOAC can be used if pt develops thrombosis. Fibrinolysis is contraindicated.
In fibrinogen disorders, using cryoprecipitate rather than fibrinogen concentrate ( 50-75 mg/mg bwt) increases risk of thrombosis.
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