Clinical options Interactive tool
General steps:
1. Establishing the diagnosis and grading the severity
2. Differential diagnosis and baseline work up
3. Empiric rx
4. Re-evaluate at 72 hr
Grade 3- self care ADL affected: "can't go to the bathroom" or grade 4- can't breathe at rest or sleep--> ER urgent evaluation. Dyspnea + fever in a pt on chemoimmunotherapy--> ER
Grade 2- " sleeping most of the day", need help with groceries i.e instrumental ADL
ASCO guideline: grade 3 ICI pneumonitis: high dose CS, stop ICI
Rx: high dose CS, if no response in 72 hr, infliximab, consider IVIG ( case reports, immunomodulatory effects, 1mg/kg bwt for 3 days)
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