Transient abnormal myelopoiesis (previously transient myeloproliferative disorder) is a clonal hematopoietic disorder unique to patients with trisomy 21.
GATA 1 mutation is the key feature. PB blasts usually between 10-30%.
TAM resolves in 80% spontaneously.
When the cells acquire additional mutations-->Down's associated leukemia--> megakaryoblastic leukemia that is distinct from the one occurring in non-DS patients
What is JMML? Pathway affected?
Juvenile myelomonocytic leukemia (JMML) is a clonal hematopoietic disorder characterized by excessive proliferation of granulocytic and monocytic lineage cells.
RAS pathway is key.
ASH ed book 2023
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